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Results in rodent models have shown that exposure to LAN accelerates mammary tumor development, increases estrogenic activity, and reduces circulating melatonin levels 159

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This can risk causing optic nerve damage and lead to blindness

Some of these events were reported in patients without known underlying renal disease

Nonetheless, administering a VEGF-upregulating compound to individuals with diagnosed or undiagnosed malignancies remains contraindicated based on precautionary clinical reasoning

Thats one reason why transdermal estrogenas opposed to oral estrogenis associated with a lower risk of blood clots