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Mukherjee U, Samanta A, Biswas S, Ghosh S, Das S, Banerjee S, et al

Since leptin reduces sweet taste sensitivity, diminished leptin signaling in the CNS may contribute to the reduced sweet taste sensitivity observed in individuals with obesity (127)

That year Charles Kimball, a biochemist, and John Murlin, a physiologist, at the University of Rochester in New York, isolated a substance in the duodenal and pancreatic mucosa of dogs that raised blood sugar levels in depancreatised dogs

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Long-term controlled safety data are absent