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Companies that challenge without thorough prior art analysis, or that underestimate the innovation in a formulation patent, tend to lose at trial

Pooled analysis of phase III trials indicate contrasting influences of renal function on blood pressure, body weight, and HbA1c reductions with empagliflozin

The higher maximum dose provides stronger appetite suppression and more weight loss

Effects of SGLT-2 inhibitors on adipose tissue distribution in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials

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The result is accelerated colonic transit in some patients, leading to looser stools and diarrhea