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Although the half-life of oral semaglutide is 1 week, once-daily administration of oral semaglutide is required to achieve therapeutic steady-state activity and to mitigate the low bioavailability and high variability in semaglutide exposure after a single oral dose (15,37)

weight reduction also supported that improvements were more pronounced for those with higher BMI and more weight loss (Supplementary Table 9)

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Its effectiveness can diminish over time, making it critical to adhere to expiration dates provided by the pharmacy or indicated on its packaging

consequently, treatment discontinuation should always be handled as an intercurrent event