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These key studies clearly provided clinical proof-of-concept that blocking the catalytic activity of DPP-4 could be a viable approach to treat T2DM, whilst at the same time helped to allay concern over whether the metabolism of any other potential DPP-4 substrates might be affected to cause unwanted off-target effects

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Acta1 is a cytoskeletal protein belonging to the actin family, Tuba1c is -tubulin, a part of the cytoskeleton, and Tubb2a and Tubb3 are known as -tubulin 51,52