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In the study of endometrial cancer (EC), we found that Brusatol sensitizes the cancer to progestins by inhibiting the NRF2-TET1-AKR1C1 pathway, which reduces AKR1C1 expression and decreases progesterone metabolism [110]

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[3] The presence of uncarboxylated proteins indicates a vitamin K deficiency

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Toxicol Sci 89, 5156

Archived from the original on 1 October 2008