8 , a020495 (2015)
10.1016/j.resmic.2015.09.006 3 AgustiA.Molina-MendozaGv.TamayoM.RossiniV.CenitMc.Frances-CuestaC.et al
Glutathione works as a potent antioxidant that helps reduce pigmentation and supports a brighter-looking complexion, while Niacinamide helps refine skin texture, minimize dullness, and strengthen the skin barrier
Statistical analysis To determine statistical significance, comparisons between two groups were performed using an unpaired Students t-test, comparisons between multiple groups were performed using a one-way ANOVA, comparisons between two or multiple groups with additional treatment conditions or repeated measurements at different time periods were performed using a two-way ANOVA, and detailed statistical analyses of high-throughput sequencing are described in the Materials and Methods section
Conversion of l-arginine to l-citrulline, when catalyzed by calcium/calmodulin-independent iNOS and -dependent eNOS (endothelial, constitutive) or nNOS (neuronal, constitutive), produces the short-lived NO
It also helps combat oxidative stress and free radicals, promoting overall skin health
