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Even though variable GSH concentrations were not tested, the authors suggested that Lys19 replacements have a negative effect on the reactivity of the glutathionylated enzyme with the reducing agent

Januvia (Sitagliptin) Sales in 2022: $4.513 billion (includes sales of Janumet (sitagliptin + metformin)) Company/Developer: Merck Date of first FDA approval: October 16, 2006 Indications Januvia is FDA-approved for: Type 2 diabetes Price of Januvia: About $613 for a supply of 30 oral 100 mg tablets Why it did so well: Januvia is a dipeptidyl peptidase-4 (DPP-4) inhibitor indicated to improve glycemic control in patients with type 2 diabetes in conjunction with diet and exercise

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