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Exclusions Case reports with fewer than 10 patients, non-English publications, and studies not specific to fibromyalgia

RTV impedes the enzyme cytochrome P450-CYP3A4, which is responsible for the metabolism of xenobiotics, and therefore RTV induces an increase in intracellular drug concentrations in the patient (Zeldin and Petruschke, 2004)

Table 12 Chemistry Panel Table 10 shows the results of the initial blood chemistry panel for 77 participants in Phase 1

Vitamin D active ligand (1,25-dihydroxyvitamin D3 or calcitriol) normally binds to the VDR nuclear receptor, forming a heterodimer with the Retinoid X Receptor (RXR), which interacts with vitamin D response elements (VDREs) to regulate gene transcription (47)

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10,15,85 During a similar interval, expression of skin collagen and elastin also reach their maximum levels