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Additionally, oxidative stress [1518] and neuroinflammation [1924] have been implicated in both SALS and FALS motor neuron degeneration and are considered important components in ALS pathogenesis

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Pharmacological agents such as fenofibrate, carnosine, umbelliferone, paricalcitol, leonurine, triptolide, DDO-1039, and Potentilla Discolor Bunge(whose main active components are quercetin, kaempferol, and -sitosterol) can upregulate NRF2, thereby suppressing ferroptosis and decelerating the progression of diabetic nephropathy [118,119,120,121,122,123,124,125,126]