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Non-alcoholic fatty liver disease (NAFLD): Oxidative stress and glutathione depletion are characteristic findings in NAFLD and its more severe form, non-alcoholic steatohepatitis (NASH)

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GSTP1 and GSTM1 do have multiple SNPs (for example, GSTP1 rs1695, A105G results in an amino acid substitution in codon 105 from valine to isoleucine associated with increased cancer risk), however, the null alleles described and focused on in this review result from gene deletion between the H3 and H5 regions flanking the gene [35]

They interfere with immune cell function and can alter cytokine production, disrupting the bodys ability to mount an effective immune response