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A convenience sample of inhabitants who live in the same geographical region were recruited as the control group

Joint pain and stiffness occur in 1525% of protocols using doses above 60 mcg daily, likely due to IGF-1s effects on collagen synthesis and extracellular water retention in synovial tissues

Peptides from several plants such as walnuts, rice bran, soybeans, quinoa, rapeseed, and flaxseed have been reported to have anti-diabetic potential

Notably, adipocytes from Gcgr / mice failed to induce lipolysis upon G49 treatment, suggesting a lipolytic action, at least in part, via GCGR as it will be discussed below

doi: 10.1038/sj.onc.1204506 34 DiasV.JunnE.MouradianM