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Targeted and constitutive colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis The claudin family of transmembrane proteins are integral to TJ structure and function

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In TNBC cells with decreased GLS expression, increased levels of carnitine palmitoyltransferase 1A/B (CPT1A/B), CPT2, and carnitine O-acetyltransferase (CRAT) may be potential predictive markers for CB-839 resistance