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doi: 10.1038/s41419-023-05859-0 81 SunWCWangNNLiRSunXCLiaoJWYangGet al

These bacteria can enter the gallbladder through the bile ducts or by lymphatic spread, causing an infection that can transform acute inflammation into a more severe form of cholecystitis

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Anyone taking methyl-donor-sensitive medications (some psychiatric drugs, methotrexate, methylated B-vitamin protocols at high doses): NNMT shares the methyl donor SAM, so theoretical interactions exist

10, 11 However, it will be necessary to confirm these results in a larger phase 3 program in obese adults, both in terms of efficacy and (particularly) safety and tolerability