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Relationship to expression profiles in other COPD studies In order to show that the gene expression signature of regional emphysema severity is present in larger cohorts of patients with earlier stages of disease, we used GSEA to examine the relationship between genes associated with regional emphysema severity in this dataset and genes associated with COPD phenotypes in other cross-sectional studies [611]

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GHK-Cu stimulates synthesis of Type I collagen (structural support) and Type III collagen (tissue flexibility and repair)

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However, the single small human study (the 2021 knee pain study) remains insufficient to establish efficacy