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Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a well-established class of glucose-lowering agents that induce glucose-mediated stimulation of insulin secretion, reduce glucagon release, reduce hepatic glucose output, delay gastric emptying, increase satiety, and improve cardiovascular risk factors (69)

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The proposed mechanisms by which GLP-1 receptor agonists affect substance use include altering dopamine release in the brains reward centers, impacting the hypothalamic-pituitary-adrenal (HPA) axis and modulating stress-related pathways, Stanford said

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