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2.2 GIPR agonism serves to reduce GLP-1R mediated GI AEs in the clinic Treatment with GLP-1R agonists can drive nausea, diarrhea, vomiting, and constipation, which often results in discontinuation of treatment (6-10% of patients) or reduction in dose (~15% of patients) (63)

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This cloudiness comes from peptide aggregation, and it means a significant portion of the active ingredient is no longer functional

Clinical studies have produced some challenging results as well

Some prescribers recommend combining with AOD 9604 for enhanced fat loss, though evidence for this combination remains limited