6H) and the production of IFN by Th1 cells is strictly dependent on glucose and aerobic glycolysis
In AD, cerebrovascular dysfunction occurs earlier among E4 carriers (Veitch et al., 2019), which could lead to impairments in nutrient sensing and metabolite exchange between the brain and periphery, thereby negatively impacting brain bioenergetics by rendering brain areas of high energetic needs (e.g., the hippocampus) vulnerable to pathologies such as amyloid (Veitch et al., 2019
Note that this direct antioxidant action likely only occurs at certain concentrations
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Mitochondrial DNA damage as driver of cellular outcomes
