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muciniphila lineages suggests that targeted modulation of specific lineages may significantly enhance therapeutic efficacy and optimize clinical outcomes, thereby overcoming the current challenge of ineffective bacterial supplementation. In addition, this bacterium exhibits a distinct dose-dependent dual effect: when present at moderate levels, it can significantly enhance the anti-tumor immune response through the induction of M1-type macrophage polarization and activation of the NLRP3 inflammasome, thereby suppressing colorectal cancer (CRC) progression [144,145,146]

10.1016/S0140-6736(09)60659-0 23 CampbellJ

Clinical manifestations and diagnosis of vitamin B12 and folate deficiency

J Obes Metab Syndr 2021;30:3205.ArticlePubMedPMC 99

Expression of hypoxia induced factor-1alpha and function of epididymis in varicocele: experiment with rats [Chinese]