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For recovery enhancement, performance optimisation, or longevity goals in healthy people, until a randomised, placebo-controlled trial in a defined population with an objective primary endpoint and pharmacovigilance over a clinically meaningful duration produces data we do not currently have, we just don't have good evidence of benefit, let alone safety

usable activity persists for several weeks even without refrigeration

Reduced stomach acid production (achlorhydria or hypochlorhydria) impairs the release of B12 from food proteins, though absorption of synthetic B12 from supplements or fortified foods remains intact