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During the MD simulations, for each Coarse-Graining model, we firstly performed a minimization step using steepest descent method to simply remove any unreasonable contacts between Coarse-Graining bends

The quantitative real-time PCR was performed using a Real-Time PCR System (Applied Biosystems, USA)

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Cao et al., in vivo (LeBlanc et al., Several NAPQI-protein adducts have been identified previously in mouse, rat, and human (Wendel and Cikryt, 1981

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