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PMID 18794148

It has a more extensive research history including human clinical trials, though efficacy results were insufficient for continued pharmaceutical development

As an exploratory outcome, we also evaluated the relationship between blood concentrations of THC and endocrine markers

3.33 mg/mL 0.060 mL 6.0 units 50 Reconstitution math only not dosing advice

We next investigated if the triple AA phospho-null mutant receptor would display any differences in its dynamic behaviour at the plasma membrane by analysing WT versus mutant receptor membrane diffusion rates by Raster image correlation spectroscopy (RICS), a technique that allows the assessment of molecular dynamics from fluorescence confocal images (18), which we have used in the past to assess the dynamic behaviour of incretin receptors (16, 19)

The titration from 0.5 mg to 1 mg at week 5 often produces the most noticeable gastrointestinal adjustment