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One possible explanation for LHS is a persistent state of chronic low-grade inflammation in the brain or spinal cord, generated by the disease or possibly by a faulty host immune response to the virus
Plasma levels decline with age, which is part of why it became a research target for skin, hair, and wound healing
doi: 10.1186/s13287-020-01753-0
Research indicates that individuals with obesity have lower immune cell activity and weaker ability to respond to pathogens (Richard et al., 2017)
The combination also has potential relevance for muscle growth protocols where researchers want to recompose body tissue rather than simply lose weight