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The key advantage of daily medications is that if you do experience initial side effects, they tend to be less intense than with weekly formulations because the dose is spread more evenly over time

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If symptoms of these allergic reactions (such as rash, skin flaking or peeling, urticaria, swelling of the skin, or swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing) occur, patients must stop taking saxagliptin and metformin hydrochloride extended-release tablets and seek medical advice promptly [see Warnings and Precautions (5.6)]