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10.1038/s41564-020-0695-z 6

Effect of daily fruit ingestion on angiotensin converting enzyme activity, blood pressure, and oxidative stress in chronic smokers

The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or Arrestin3 effectively

Persistent symptoms may warrant a dose adjustment, a temporary acid-suppressing medication (like omeprazole), or investigation into whether an underlying condition like gastroesophageal reflux disease (GERD) is being unmasked by the tirzepatide's effects

Start with a loading phase of 20g per day for 5-7 days, divided into 4 doses

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