The assay is based on the conversion of citrate to isocitrate, to -ketoglutarate, which results in the production of NADPH
Within the hypothalamus, brain CPT1C serves as a sensor of nutrient availability by binding malonyl-CoA which triggers a reduction in the release of the appetite promoting neuropeptides, neuropeptide Y (NPY) and Agouti-related peptide (AgRP) and an increase in the release of the appetite suppressing neuropeptides, -melanocyte stimulating hormone (-MSH) and cocaine and amphetamine regulated transcript (CART)
Evidence-Based Complementary and Alternative Medicine, 2020, 7525713
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