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10.1016/j.nbd.2005.08.014 109 GiaumeC.LeybaertL.NausC

Potential masking of underlying hepatic or systemic disease Delayed diagnosis due to symptom suppression Medical supervision is essential to ensure appropriate patient selection, correct dosing, and timely identification of adverse reactions

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Moreover, it promoted the co-localization of LC3 with KEAP1 (Fig

Highlights Ubx homodimerization enables decoupling of DNA- and RNA-dependent splicing regulation The homeodomain K58 amino acid is critical for Ubx-RNA binding ability Ubx-RNA binding ability is essential for splicing regulation Dual DNA/RNA binding activities shape Ubx homeotic functions INTRODUCTION Transcription factors (TFs) play a critical role in coordinating the development of multicellular organisms by regulating precise gene expression programs 1,2