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Their seemingly miraculous properties have been praised by tech CEOs, podcaster Joe Rogan, and celebrities such as Gwyneth Paltrow, Jennifer Aniston, and Kim Kardashian, who says her daily regimen changed my life. But many doctors are alarmed by a craze that has thousands of people injecting themselves with substances of dubious origin and whose long-term effects are unknown

However, univariate GLM with age as a covariate revealed other neurochemical abnormalities in the pgACC, notably in concentration of lactate (F = 4.684, p = 0.013) (Fig