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The key principle is achieving gradual, sustained weight loss rather than rapid reduction

b , Mouse brain images showing heatmap of averaged changes in cFOS expression in response to treatments relative to vehicle

It's a structurally distinct molecule with a fundamentally different receptor binding profile

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Additionally, polyphyllin I reduced the inhibitory effect of lncRNA-ROR on tumor growth, and induced intrinsic and extrinsic apoptosis in nasopharyngeal carcinoma cells, thereby enhancing p53 signaling transduction [86]