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This natural decline is one of the core reasons skin appears thinner over time, but peptides like GHK-Cu have been shown to help stimulate new collagen production

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It works closely with folate to ensure proper cell division

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As an example of such a multipronged approach, the Neotone formulation simultaneously targeting melanocytes, fibroblasts, and endothelial cells with the combination of five actives (niacinamide, licorice extract, diacetylboldine, a DKK1 agonist, and an inhibitor of EDN-1 synthesis) was found to be as effective as hydroquinone 4% cream in the management of facial melasma, while inducing fewer side effects [214]