47 Visceral fat accumulation in patients with obesity causes a number of changes (oxidative stress, activation of the RAAS and gut dysbiosis), resulting in insulin resistance, increased vascular stiffness, T2D, dyslipidaemia, hypertension, coronary atherosclerosis and, ultimately, HFpEF
Furthermore, in the context of polypharmacy, gastrointestinal side effects may have heightened clinical relevance, underscoring the importance of patient-based risk assessment in clinical practice
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