doi:10.1211/pj.2025.1.375713 47.Koskinas KC, Van Craenenbroeck EM, Antoniades C, et al
Cureus 15(10) Miranda S et al (2025) Impact of semaglutide on lipid profiles in overweight and obese non-diabetic adults: a systematic review and meta-analysis of randomized controlled trials
My concern is that these meds don't fix the habits, emotional dysregulation, & lack of movement/exercise that often lead to obesity Neither do they fix the fact our current food system in much of the world is full of frankenfoods which are designed to promote overeating, or structural issues around the pressures on people which mean they don't have time or money to eat healthier more expensive less processed food, or move more I'm also concerned that - even for people that the above isn't a concern - that there isn't the appropriate support given as standard around nutritional education, lifestyle modification, resistance training, & emotional/mindset repatterning which are vital for ensuring that what people are eating is optimal for long term health and that they're taking the necessary actions to preserve muscle Thank you for this scientifically rigorous but also humane breakdown Lucy Jones - it is extremely important to have dietetic & nutritional perspective on this highly emotive issue
Apolipoprotein E: far more than a lipid transport protein
Several positions use non standard or stereochemically specified residues
Even so, some scientists tell C&EN that amyloid therapies have been important forerunners, pushing the field toward better diagnostics, better tools to monitor brain pathology, and better trial design
