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It is speculated that this signaling may be mediated by CREB, which is known to act downstream of GLP-1R and may influence the transcription of IL-6 [122,123,124]

Additionally, 53% of participants were on SUs

Ethics statement Skin biopsy samples used in this manuscript and animal experiments were approved by the local ethics committee and the institutional review board of Huashan Hospital and conducted in accordance with the Helsinki declaration

We first examined the concentration-dependent effect of PFOS on mitochondrial bioenergetics and discovered that an increase in the PFOS concentration from 100 to 200 M significantly decreased mitochondrial bioenergetics, as evidenced by the decreased ATP production, maximal respiration and spare respiratory capacity, and increased proton leakage (Fig

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