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The dosage can be gradually increased if no discomfort occurs

Dose escalation beyond the receptor saturation threshold increases systemic exposure, raises the risk of off-target effects (HGF receptors exist in liver, kidney, and vascular tissue), and wastes expensive research compounds

This interrupts negative feedback signaling in the pituitary gland of the brain, resulting in increased release of the ovary-activating hormones, follicle stimulating hormone (FSH) and luteinizing hormone (LH)

Our structures also provide clues for understanding the mechanism of the basal activity of the ghrelin receptor

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10.5009/gnl18490 67 SikiricP.DrmicD.SeverM.KlicekR.BlagaicA