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Eur Heart J 36:2288-2296

In AML, SIRT3 activity has been implicated in chemoresistance to Ara-C by regulating OxPhos in the myeloid cell line MV4-11 (Ma et al., 2019)

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Key findings from the Phase 2 trial included: Dose-dependent weight loss , with greater reductions observed at higher doses Significant improvements in waist circumference , blood pressure , and lipid profiles Reductions in fasting glucose and insulin resistance markers, though the clinical significance of these findings in people with type 2 diabetes requires further investigation Weight loss appeared to continue throughout the 48-week period without a clear plateau at the highest doses Whilst these results are encouraging, it is important to contextualise them appropriately