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However, exenatide had a statistically significant greater effect in these clinical outcomes compared to sitagliptin

and Eli Lilly, the maker of tirzepatide, the active ingredient in Zepbound, warn about medications claiming to be the compounded versions of brand-name GLP-1 weight-loss drugs

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According to a May 2022 update by the World Health Organization, there are currently about 2 billion adults with overweight and 650 million with obesity

This could be due to better muscle signaling or reduced inflammatory cytokines , though more research is needed