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Desensitization Protocols Desensitization protocols involve gradually exposing the body to increasing amounts of progesterone to build up tolerance and decrease sensitivity 9

These are pathway-level markers, not response predictions

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However, with Eli Lillys Orforglipron already in Phase III clinical trials, prolonged preclinical studies for HS-10535 could result in a missed market opportunity

Factors including adherence, lifestyle habits, underlying health conditions, and dose tolerance all affect how treatment progresses