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For example, Bifidobacterium bifidum [138], with its hypoxia tropism, has been used to covalently modify calcium phosphate/silica nanoparticles loaded with doxorubicin, constructing the DNPs@Bi system that can actively target chemotherapy drugs to the hypoxic core of tumors, achieving effective killing of solid tumors through the combination of chemotherapy and immunogenic cell death effects

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Its broad interaction with biological systems has made it a commonly referenced compound in experimental research environments

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