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Overdose depletes glutathione entirely, but even therapeutic doses can increase glutathione turnover and sometimes lower antioxidant capacity

(PubMed) Mares JA, Voland RP, Sondel SA, et al

RNA-seq data generated in this study have been deposited in the SRA database under accession code BioProject PRJNA1249006

Beyond sleep, researchers have studied DSIP for its effects on stress hormone regulation specifically its ability to modulate ACTH and cortisol secretion making it of interest in HPA axis research

The risk is greater with longer duration of use but decreases significantly following cessation (133)

Exp Biol Med (2011) 236(11):12318