0.5 mg/0.1 ml saline/each eye) in rats immediately produced moderate generalized irregularity in the diameter of blood vessels with moderate atrophy of the optic disc and faint presentation of the choroidal blood vessels, and these lesions rapidly progressed to the severe stage
and it modulates the FAK-paxillin pathway, enhancing migration of fibroblasts to the injury site for collagen deposition
For those with deficiencies or certain health conditions that impede nutrient absorption from food sources alonesuch as pernicious anemia or gastrointestinal disordersa direct injection can be life-changing
In self-administered 36 IU IN OT patients, morning plasma OT levels did not change following chronic IN OT or with weight restoration
Heres what current research tells us: The Evidence For a Connection Several studies have found associations between low B12 and hair problems: A case-control study of patients with chronic telogen effluvium (a common form of diffuse hair shedding) found that 60% had B12 deficiency , significantly higher than the control group Research in pregnant women with severe hair loss showed significantly lower vitamin B12 levels compared to those without hair loss Multiple studies, particularly from India, have found higher rates of B12 deficiency among patients experiencing hair shedding B12 deficiency has been strongly linked to premature greying one study found significantly lower B12, folate, and biotin levels in people with premature grey hair (greying before age 20-30) The Mixed Picture However, not all studies agree: A 2019 literature review concluded there is currently insufficient evidence to recommend B12 supplementation for hair loss in those without confirmed deficiency Three Turkish studies totalling 147 patients with alopecia areata found no difference in B12 levels between those with hair loss and healthy controls One study specifically evaluating B12 levels found that reducing B12 had no adverse effects on hair shedding or growth The Bottom Line The research suggests that: If youre B12 deficient , correcting the deficiency may help improve hair health If youre not deficient , B12 supplementation is unlikely to boost hair growth B12 deficiency appears more strongly linked to premature greying than to hair loss itself Hair loss is typically multifactorial B12 may be one contributing factor among several This is precisely why testing is so important
they cause an altered expression of defensin genes, thus facilitating an impaired antimicrobial response to the gut microbiota and promoting the translocation of the bacteria across the epithelium [40]
