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In plasma, taurine and hypotaurine metabolism were represented among the decreased metabolites during regeneration, and branched chain amino acid biosynthesis was highly represented among the increased metabolites (Extended Data Fig

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The detected correlation may alternatively stem from unmeasured variations in patients baseline vascular health, advanced metabolic severity, or underlying diabetic complications, rather than a direct cellular effect of the GLP-1 molecules themselves

By measuring the transcriptome and metabolome of the LDH1 knockout strain ( ldh1 ) under LA stress and comparing it with the wild-type strain BY4741, we found that under the condition of LDH1 knockout, the accumulation of NAD + intermediates would be activated, disrupting normal cell functions and causing cell damage

PMID: 27401139