In PD, GLP-1RAs prevented the progression of loss of nigrostriatal dopaminergic cells, restored dopamine synthesis, showed anti-inflammatory activity, and improved motor functions [45]
The neuroprotective effect is perhaps the most significant because in neurodegenerative diseases such as Alzheimer's disease or Parkinson's disease, it may save cells from deterioration induced by specific agents
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Surprisingly, duloxetine decreased serum BDNF level significantly in the FM patients even after adjusting for the disease severity, depression, and pain level
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