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But from an individual's perspective, it's changing lives. Practical questions for HR: philosophy, caps and proactive strategy Even with strong cardiovascular evidence, plan sponsors operate within real constraints, and Mapleston explains that insurers must manage pooled risk across many employers, and employers must respect employee autonomy and physician judgment: Employer and insurance carriers can't control how long someone stays on a medication. From an HR policy perspective, that means evidence can inform plan design but cant be used to require adherence

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In humans, acute intravenous infusion of PYY(336) has consistently been shown to reduce hunger and food intake in a dosedependent manner (by approximately onethird), an effect observed in both lean and obese individuals (154)

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