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Materials and methods Ethic statements The animal studies were carried out in strict accordance with the Detailed Rules for the Administration of Animal Experiments for Medical Research Purposes issued by the Ministry of Health of the Peoples Republic of China and were approved by the Animal Experiment Administration Committee of The Fourth Military Medical University

Some studies also evaluate receptor-mediated interactions within metabolic and neurobiological research frameworks

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Mitochondrial dysfunction and expression of apoptotic proteins, such as active caspase-3, Bax, and Bcl-2 caused by low levels (0.75 mg/kg) of AFB 1 can finally cause severe cardiomyocyte dysfunction (129)

PPARgamma modulates vascular smooth muscle cell phenotype via a protein kinase G-dependent pathway and reduces neointimal hyperplasia after vascular injury