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En las ratas obesas prediabticas OLETF (Otsuka-Long-Evans-Tokushima Fatty rats) se observ que despus de 12 semanas de tratamiento con la liraglutida exista una adecuada conservacin de la morfologa de los islotes pancreticos, regulacin a la alta de la expresin de factor antiapopttico Bcl-2 y regulacin a la baja de la expresin del factor proapopttico Bax, resultados que sugieren que la liraglutida tiene un papel protector en la formacin y la funcin del islote pancretico mediante el control de las vas apoptticas, lo que permite mantener la funcin endocrina de la clula beta y prevenir las alteraciones de la glucosa y la aparicin de DM244

The local recurrence rate was 60% and and 1

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Bardgett et al., 2015), behavioral (Bale and Vale, Following the characterization of CRF, additional structurally related members of the CRF peptide family were identified, namely urocortin 1 (Ucn 1, 40 amino acids, 45% sequence homology with rat/human CRF) (Vaughan et al., 1995), Ucn 2 (39 amino acids, 34% sequence homology with rat/human CRF) (Reyes et al., 2001) and Ucn 3 (38 amino acids, 26% sequence homology with rat/human CRF) (Lewis et al., Mapping studies identified prominent CRF expression in the cerebral cortex, amygdala, hippocampus and the Barrington's nucleus in rodents (Wang et al., 2011)

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