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Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment
She had gained 16.4 kg (36 lbs.), causing a dramatic progression of her lymphedema: her impairment score nearly tripled, and her limb volume increased from 1.7% to greater than 10% despite compression and physiotherapy
From a mechanistic standpoint, there's no basis for a pharmacological interaction
The strong presence of leading branded injectable therapies continues to drive revenue generation across major markets
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[2] Choline chloride serves as an essential substrate for phosphatidylcholine and betaine formation, thereby enhancing bile-dependent lipid emulsification and acting as an osmolyte that maintains hepatocyte membrane integrity under oxidative stress
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