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Sermorelin typically works gradually, with improvements in sleep and energy showing up within a few weeks and other changes over a few months

Hepatology 71 , 16781695 (2020)

Progress in Neurobiology 2000

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It is counterintuitive, but one of the cleaner randomized Alzheimers trials found exactly that: a 10 mL daily dose improved both cognition and global function, while higher 30 and 60 mL doses helped global function but not cognition, a reversed-U pattern where more was not better