Other clinical and utility inputs (eg, baseline CVD prevalence, stroke disutility, D&E-arm weight loss) produced modest changes relative to the main drivers
Overview of the Phase 2 NEJM Trial Design and Participants The phase 2 trial was a randomised, double-blind, placebo-controlled, dose-ranging study enrolling 338 adults with obesity or overweight without type 2 diabetes, assessing retatrutide doses of 1 mg, 4 mg, 8 mg, and 12 mg over 48 weeks
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NE u was significantly reduced in young high-BMI subjects vs young low-BMI subjects
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