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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

Exalto, L

Patients can search for registered trials via: NIHR Be Part of Research (bepartofresearch.nihr.ac.uk) the primary UK public-facing trial finder ClinicalTrials.gov for international trial listings including TRIUMPH studies ISRCTN Registry (isrctn.com) for UK-registered trials Note that the EU Clinical Trials Register primarily covers trials registered in EU member states and may not list UK-based trials following the UK's departure from the EU

Its ability to recycle these antioxidants ensures sustained cellular defense against oxidative stress, helping maintain the integrity of skin, organs, and tissues over time

BPC-157 research examines early growth response gene-1 (egr-1) upregulation and its relationship to collagen organization timing