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Protocol registration The study follows a predefined protocol for pharmacovigilance signal detection and complies with WHO and UMC guidelines for disproportionality analysis

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As shown in Table 1, we explored the synthesis of the JR sequence using variable amounts of pyrrolidine base under variable deprotection times and resins both with and without additional nitrogen headspace flushing, keeping coupling conditions the same for all experiments

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Kangxi arranged for his whole family to be variolated, an early form of immunization in which healthy individuals were deliberately inoculated